Anhydrobiosis is the state of life in which an organism has lost virtually all intracellular water but is capable of resuming its biological processes and life cycle upon rehydration. 

The molecular mechanisms governing anhydrobiosis are still largely unknown and entail a complex array of mechanisms that are carefully orchestrated by certain intrinsically disordered proteins and osmolytes including trehalose.

Late embryogenesis abundant (LEA) proteins form a large subgroup of anhydrobiosis-related intrinsically disordered (ARID) proteins, and were named for their high expression during late embryogenesis in cotton seeds.